Lipstick Jungle is a dramedy that follows the professional and personal lives of three best friends, all of whom are top professionals in their respective careers. Victory Ford (Price) is a fashion designer, Nico Reilly (Raver) is the editor-in-chief of Bonfire Magazine, and Wendy Healy (Shields) is the former president of Parador Pictures and is now producing independently. These three powerful women are always there to support one another and navigate the crazy, romantic, and sometimes scary world that is New York City. Victory is planning to propose to Joe; Shane's thoughts of going on tour with Natasha Bedingfield, has Wendy upset; and problems at work have Nico and Griffin bonding. Nico has a lot on her mind as she butts heads with the new CEO Griffin Bell and Kirby complicates matter when he insists on taking their relationship out in public. Meanwhile, things are heating up quickly for Victory and her new contractor Rodrigo, but problems arise when Joe constantly interrupts her new relationship. Later, Victory gets a surprise when Rodrigo shares that he has another woman in his life. Elsewhere, Wendy is consumed by her new John Lennon project, which begins to affect her personal and professional life. Nico is haunted by her infidelity when Charles gives her a photograph that Kirby took of her during their affair. Overcome with guilt, she debates whether she should tell Charles the truth and decides to go to extreme measures to save her marriage. Wendy decides to cut back on her hours at the office and spend more time at home after she finds her under-age daughter, Maddie, at a bar. Her transition into domestic life is not an easy one especially when her opinionated mother unexpectedly comes to the city for a visit. Victory finds it difficult to avoid Joe who is desperate to get her back. Trying to move on from their personal relationship, she hires a publicist Dahlia Morales to help brand her business and find a retail space. Nico and Wendy go on a business trip to Scotland; Victory grows suspicious of her newfound investor. Victory discovers that someone has stolen her designs and learns a trusted, former employee has betrayed her. Wendy, unwittingly, uses her position to rejuvenate her husband's music career by getting him a job composing for one of her movies. Nico continues her affair with Kirby but she's finding it hard to follow her own rules for the relationship and must battle her own jealousy.