Frankie Heck and her husband Mike have lived in Orson, Indiana, their whole lives. A man of few words (every one a zinger), Mike is a manager at the town quarry and Frankie is the third-best used car salesman (out of the three) at the local dealership. She may not be a high-powered career woman, but when it comes to her family, she'll go to just about any length. And with kids like these, she had better. There's Axl, her semi-nudist teenage son conceived while under the influence of Guns N' Roses; Sue, the awkward teenage daughter who fails at everything... but with the utmost of gusto; and their seven-year-old son Brick, whose best friend is his backpack. Sometimes it seems like everyone is trying to get to the top, or struggling not to hit bottom, but we think Frankie and her family will find a lot of love, and a lot of laughs, somewhere in "The Middle". A Heck leaves the nest as the family takes a road trip to Denver, where Axl will start his new job - and new life away from home. Frankie is surprised but relieved when Dr. Goodwin agrees to buy all of the peanut brittle that Brick needs to sell for school. But the good doctor displays a bit of Mr. Hyde behavior when Frankie doesn’t deliver the product in an expeditious manner. Meanwhile, Axl is getting sick and tired of having Mike tell him how to run his life; and things go off the rails when Axl attempts to trade in the Winnebago and buy a car. Sue is more determined than ever to win a very prestigious and competitive hotel scholarship; and Frankie swears that she’s seeing something mysterious flying through the house.