(reUpload) Coursera - Virology II How Viruses Cause Disease
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- TypeTutorials
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- Uploaded ByGigaWail
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- Last checkedNov. 09th '19
- Date uploadedNov. 08th '19
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Virology II How Viruses Cause Disease
Columbia University via Coursera
Overview
This introductory virology course explores the interplay between viruses and their host organisms. The course begins with an overview of how infection is established in a host, then moves to a virologist's view of immune defenses. Next we consider how the replication strategy and the host response determine the outcome of infection, such that some are short and others are of long duration. The mechanisms by which virus infections transform cells in culture are explored, a process that may lead to tumor formation in animals. We then move to a discussion of how viral infections are controlled by vaccines and antiviral drugs. After an introduction to viral evolution, we discuss the principles learned from zoonotic infections, emerging infections, and humankind's experiences with epidemic and pandemic viral infections. The course ends with an exploration of unusual infectious agents such as viroids, satellites, and prions, followed by a discussion of the causative agent of the most serious current worldwide epidemic, HIV-1.
Syllabus
Week 1
Infection basics
Entry into the host
Viral spread
Tissue invasion and tropism
Transmission and seasonality
Week 2
Innate immune responses
Interferon
Sentinels and complement
Inflammation
Adaptive immunity
Week 3
Viral virulence
Mechanisms of cell injury I
Mechanisms of cell injury II
Host susceptibility
Week 4
Acute infections
Influenza
Poliomyelitis
Measles
Gastroenteritis
West Nile fever
Week 5
Persistent infections
Persistence by modulating the adaptive response
Two persistent infections
Herpes simplex virus
Epstein-Barr virus
Week 6
Transformation
RNA tumor viruses
Transforming retroviruses
DNA tumor viruses
Epiphenomena of a unique life style
Week 7
Vaccines
How do you make a vaccine?
Inactivated vaccines
Attenuated vaccines
Week 8
Antivirals
Antiviral discovery
Antiviral resistance
Other antiviral targets
HIV antivirals
Week 9
Viral evolution
Drivers of evolution
Error threshold and bottlenecks
Selection
Origins of viruses
Week 10
Emerging viruses
Host-virus interactions
Examples of emerging viruses
SARS and MERS
Canine parvovirus
Week 11
Viroids
Satellites
Transmissible spongiform encephalopathies
Prions
Week 12
HIV and AIDS
The origin of HIV
HIV pathogenesis
An amazing but deadly virus
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Files:
Virology II How Viruses Cause Disease- How Viruses Cause Disease W11 S4 Prions (2654).mp4 (71.3 MB)
- How Viruses Cause Disease Review - Welcome to Virology (2134).mp4 (17.0 MB)
- How Viruses Cause Disease Review - What is a Virus (1439).mp4 (41.4 MB)
- How Viruses Cause Disease W1 Introduction.mp4 (13.4 MB)
- How Viruses Cause Disease W1 S1 Infection basics (1516).mp4 (36.4 MB)
- How Viruses Cause Disease W1 S2 Entry into the host (1128).mp4 (30.6 MB)
- How Viruses Cause Disease W1 S3 Viral spread (1911).mp4 (49.6 MB)
- How Viruses Cause Disease W1 S4 Tissue invasion and tropism (1115).mp4 (30.8 MB)
- How Viruses Cause Disease W1 S5 Transmission and seasonality (1520).mp4 (42.1 MB)
- How Viruses Cause Disease W2 Introduction.mp4 (8.2 MB)
- How Viruses Cause Disease W2 S1 Innate immune responses (1727).mp4 (50.6 MB)
- How Viruses Cause Disease W2 S2 Interferon (1332).mp4 (31.9 MB)
- How Viruses Cause Disease W2 S3 Sentinels and complement (1229).mp4 (33.4 MB)
- How Viruses Cause Disease W2 S4 Inflammation (11 29).mp4 (31.3 MB)
- How Viruses Cause Disease W2 S5 Adaptive immunity (1752).mp4 (49.4 MB)
- How Viruses Cause Disease W3 Introduction.mp4 (11.8 MB)
- How Viruses Cause Disease W3 S1 Viral virulence (2304).mp4 (52.1 MB)
- How Viruses Cause Disease W3 S2 Mechanisms of cell injury I (1852).mp4 (48.8 MB)
- How Viruses Cause Disease W3 S3 Mechanisms of cell injury II (1305).mp4 (35.9 MB)
- How Viruses Cause Disease W3 S4 Host susceptibility (1355).mp4 (35.3 MB)
- How Viruses Cause Disease W4 Introduction.mp4 (8.2 MB)
- How Viruses Cause Disease W4 S1 Acute infections (1138).mp4 (25.1 MB)
- How Viruses Cause Disease W4 S2 Influenza (1557).mp4 (36.9 MB)
- How Viruses Cause Disease W4 S3 Poliomyelitis (818).mp4 (23.9 MB)
- How Viruses Cause Disease W4 S4 Measles (930).mp4 (21.6 MB)
- How Viruses Cause Disease W4 S5 Gastroenteritis (1427).mp4 (36.1 MB)
- How Viruses Cause Disease W4 S6 West Nile fever (659).mp4 (16.3 MB)
- How Viruses Cause Disease W5 Introduction.mp4 (9.4 MB)
- How Viruses Cause Disease W5 S1 Persistent infections (1006).mp4 (19.8 MB)
- How Viruses Cause Disease W5 S2 Persistence by modulating the adaptive response (2628).mp4 (60.2 MB)
- How Viruses Cause Disease W5 S3 Two persistent infections (1128).mp4 (13.6 MB)
- How Viruses Cause Disease W5 S4 Herpes simplex virus (2042).mp4 (24.7 MB)
- How Viruses Cause Disease W5 S5 Epstein-Barr virus (1210).mp4 (29.3 MB)
- How Viruses Cause Disease W6 Introduction.mp4 (9.3 MB)
- How Viruses Cause Disease W6 S1 Transformation (1701).mp4 (44.4 MB)
- How Viruses Cause Disease W6 S2 RNA tumor viruses (1420).mp4 (37.9 MB)
- How Viruses Cause Disease W6 S3 Transforming retroviruses (1422).mp4 (18.0 MB)
- How Viruses Cause Disease W6 S4 DNA tumor viruses (941).mp4 (26.5 MB)
- How Viruses Cause Disease W6 S5 Epiphenomena of a unique lifestyle (1223).mp4 (29.0 MB)
- How Viruses Cause Disease W7 Introduction.mp4 (10.3 MB)
- How Viruses Cause Disease W7 S1 Vaccines (1529).mp4 (18.9 MB)
- How Viruses Cause Disease W7 S2 How do you make a vaccine (1314).mp4 (16.7 MB)
- How Viruses Cause Disease W7 S3 Inactivated vaccines (1432).mp4 (18.5 MB)
- How Viruses Cause Disease W7 S4 Attenuated vaccines (1850).mp4 (22.9 MB)
- How Viruses Cause Disease W8 Introduction.mp4 (10.4 MB)
- How Viruses Cause Disease W8 S1 Antivirals (1257).mp4 (31.9 MB)
- How Viruses Cause Disease W8 S2 Antiviral Discovery (1857).mp4 (23.8 MB)
- How Viruses Cause Disease W8 S3 Antiviral Resistance (1958).mp4 (50.2 MB)
- How Viruses Cause Disease W8 S4 Other antiviral targets (608).mp4 (16.4 MB)
- How Viruses Cause Disease W8 S5 HIV antivirals (1313).mp4 (37.3 MB)
- How Viruses Cause Disease W9 Introduction.mp4 (10.9 MB)
- How Viruses Cause Disease W9 S1 Viral evolution (549).mp4 (13.2 MB)
- How Viruses Cause Disease W9 S2 Drivers of evolution (1731).mp4 (44.5 MB)
- How Viruses Cause Disease W9 S3 Error threshold and bottlenecks (1614).mp4 (39.1 MB)
- How Viruses Cause Disease W9 S4 Selection (1428).mp4 (38.3 MB)
- How Viruses Cause Disease W9 S5 Origin of Viruses (1247).mp4 (33.1 MB)
- How Viruses Cause Disease W10 Introduction.mp4 (8.9 MB)
- How Viruses Cause Disease W10 S1 Emerging viruses (1121).mp4 (30.4 MB)
- How Viruses Cause Disease W10 S2 Host-virus interactions (1605).mp4 (36.3 MB)
- How Viruses Cause Disease W10 S3 Examples of emerging viruses (1835).mp4 (52.9 MB)
- How Viruses Cause Disease W10 S4 SARS and MERS (1547).mp4 (19.7 MB)
- How Viruses Cause Disease W10 S5 Canine parvovirus (425).mp4 (11.0 MB)
- How Viruses Cause Disease W11 Introduction.mp4 (9.2 MB)
- How Viruses Cause Disease W11 S1 Viroids (1842).mp4 (22.8 MB)
- How Viruses Cause Disease W11 S2 Satellites (1956).mp4 (25.1 MB)
- How Viruses Cause Disease W11 S3 Transmissible spongiform encephalopathies (1041).mp4 (27.8 MB)
- How Viruses Cause Disease Review - Viruses Then and Now (1458).mp4 (47.3 MB)
- How Viruses Cause Disease W12 Introduction.mp4 (14.8 MB)
- How Viruses Cause Disease W12 S1 HIV-1 and AIDS (1331).mp4 (35.5 MB)
- How Viruses Cause Disease W12 S2 The origin of HIV (2338).mp4 (30.6 MB)
- How Viruses Cause Disease W12 S3 HIV pathogenesis (1528).mp4 (19.5 MB)
- How Viruses Cause Disease W12 S4 An amazing but deadly virus (1013).mp4 (12.9 MB)
Code:
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